Thy-1+ dendritic epidermal cells belong to the T-cell lineage.

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Thy-1+ dendritic epidermal cells belong to the T-cell lineage.

The murine epidermis contains a population of dendritic, Thy-1+ cells (Thy-1+ DEC). Although it is now clear that these cells are of bone marrow origin, extensive morphological, histochemical, and cell-membrane marker studies have not definitively placed them in any known hematopoietic differentiation pathway. Based on the observation that Thy-1+ DEC can be propagated in vitro with Con A and in...

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Human Epidermal T Cells Predominately Belong to the Lineage Expressing

Normal human epidermis, long since dismissed as merely a protective covering for the body, is now recognized as a complex immunological unit . This concept is based on the demonstration that Langerhans cells (LCs)t are potent APCs for a variety of T cell (TC) responses and that keratinocytes (KC), at least upon stimulation, can secrete a plethora of immunomodulating cytokines (reviewed in refer...

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Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor

The epidermis of clinically normal-appearing human skin harbors a phenotypically heterogeneous population of T lymphocytes (TCs), the majority of which are CD2+/CD3+/CD5+ "memory" cells, but in an unactivated state, and express the TCR-alpha/beta. In contrast to murine skin, only a very minor subpopulation of CD3+ cells in the human epidermis bears the TCR-gamma/delta. Epidermal TCs primarily a...

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The Potential of Menstrual Blood-Derived Stem Cells in Differentiation to Epidermal Lineage: A Preliminary Report

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1987

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.84.8.2430